Lithium hydroxide, monohydrate → lithium (R)-4-(1-(1-(3-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate
Reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[C:13]([NH:15][C:16]1([C:19]2[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=2)[CH2:18][CH2:17]1)=[O:14].O[Li:35].O>>[F:32][C:2]([F:1])([F:33])[C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[C:13]([NH:15][C:16]1([C:19]2[CH:28]=[CH:27][C:22]([C:23]([O-:25])=[O:24])=[CH:21][CH:20]=2)[CH2:18][CH2:17]1)=[O:14].[Li+:35]Participants
3
Procedure
The title compound (E9) (51 mg) was prepared according to the general procedure for esters hydrolysis starting from (R)-methyl 4-(1-(1-(3-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate (D26) (76 mg). (LiOH H2O: 3 eq; reaction time: 3 hrs)
Sources & evidence
- ORD record
- ord-1750585377cd450e9525d85a9cb1a519
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09120824B2
Reaction notes
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