Lithium hydroxide, monohydrate → lithium (R)-4-(1-(1-(3-methylbenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][CH:30]=1)[CH2:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][C@@H:7]1[C:12]([NH:14][C:15]1([C:18]2[CH:27]=[CH:26][C:21]([C:22]([O:24]C)=[O:23])=[CH:20][CH:19]=2)[CH2:17][CH2:16]1)=[O:13].O[Li:32].O>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][CH:30]=1)[CH2:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][C@@H:7]1[C:12]([NH:14][C:15]1([C:18]2[CH:19]=[CH:20][C:21]([C:22]([O-:24])=[O:23])=[CH:26][CH:27]=2)[CH2:16][CH2:17]1)=[O:13].[Li+:32]Participants
3
Procedure
The title compound (E10) (61 mg) was prepared according to the general procedure for esters hydrolysis starting from (R)-methyl 4-(1-(1-(3-methylbenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate (D27) (63 mg). (LiOH H2O: 3 eq; reaction time: 3 hrs)
Sources & evidence
- ORD record
- ord-6c613ddeb6484e98a73797b0d6861baa
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09120824B2
Reaction notes
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