Hydrochloric Acid → HCID 178465949, compound

HRID 227332Notes

Reaction equation

HRID 227332 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[C:7]2=[C:14]([N:21](OC)[CH2:22][C:23]([OH:25])=[O:24])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:3])[CH3:2].CO.Cl>[OH-].[Na+]>[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[C:7]2=[C:14]([NH:21][CH2:22][C:23]([OH:25])=[O:24])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 86600732HCID 86600732, compound

Product 1

HCID 178465949HCID 178465949, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

88 mg (0.25 mmol) 5-acetyl-3-[(methoxycarboxymethyl-amino)-phenyl-methylidene]-2-indolinone (Example 1.005) are suspended in 0.5 ml 1 N sodium hydroxide solution and 5 ml of methanol and refluxed for 4 h. Then the mixture is cooled, 0.5 ml 1 N hydrochloric acid are added and the precipitate is removed by suction filtering.

Workup

  1. temperatureThen the mixture is cooled
  2. customthe precipitate is removed by suction
  3. filtrationfiltering

Sources & evidence

ORD record
ord-c01f77f0e9de40b38777b50187d91e0b
Source dataset
uspto-grants-2009_07
Patent number
US07560480B2

Reaction notes

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