HCID 86692718, compound → HCID 86692719, compound

HRID 2273344Notes

Reaction equation

HRID 2273344 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([S:21](=[O:24])(=[O:23])[NH2:22])=[CH:17][CH:16]=1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([S:21]([NH2:22])(=[O:23])=[O:24])=[CH:19][CH:20]=1

Participants

4

Reactant 1

HCID 86692718HCID 86692718, compound

Product 1

HCID 86692719HCID 86692719, compoundYield 193.3%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl(6-(4-sulfamoylphenoxy)hexyl)carbamate (1.178 g, 3.16 mmol) in TFA (5.0 mL) and DCM (5.0 mL) was stirred at rt for overnight. After the solvent was evaporated under a steam of N2, the reaction mixture was dissolved in water (5.0 mL) and acetonitrile (5.0 mL) and lyophilized to afford 4-((6-aminohexyl)oxy)benzenesulfonamide (1.664 g) containing TFA. MS (ESI), 273.1 (M+H)+.

Workup

  1. customAfter the solvent was evaporated under a steam of N2
  2. dissolutionthe reaction mixture was dissolved in water (5.0 mL)

Sources & evidence

ORD record
ord-e1591458ed3945d08e281781ec2b82f7
Source dataset
uspto-grants-2015_09
Patent number
US09120837B2

Reaction notes

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