Potassium Carbonate → HCID 57500343, compound

HRID 2273526Notes

Reaction equation

HRID 2273526 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH2:7]([O:14][C:15]1[C:23]2[N:19]([C:20]([C:27]([C:29]3[CH:30]=[CH:31][C:32]([NH:39]C(=O)C(F)(F)F)=[C:33]([CH:38]=3)[C:34]([O:36][CH3:37])=[O:35])=[O:28])=[C:21]([CH3:26])[C:22]=2[O:24][CH3:25])[CH:18]=[CH:17][CH:16]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CO.ClCCl>[NH2:39][C:32]1[CH:31]=[CH:30][C:29]([C:27]([C:20]2[N:19]3[C:23]([C:15]([O:14][CH2:7][C:8]4[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=4)=[CH:16][CH:17]=[CH:18]3)=[C:22]([O:24][CH3:25])[C:21]=2[CH3:26])=[O:28])=[CH:38][C:33]=1[C:34]([O:36][CH3:37])=[O:35]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 57500341HCID 57500341, compound

Product 1

HCID 57500343HCID 57500343, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

1.15 g (8.33 mmol) of potassium carbonate are added to the solution of 0.90 g (1.67 mmol) of methyl 5-{[8-(benzyloxy)-1-methoxy-2-methylindolizin-3-yl]carbonyl}-2-[(trifluoroacetyl)amino]benzoate in 100 ml of methanol and 100 ml of dichloromethane. The mixture is stirred at ambient temperature for 20 hours. The yellow precipitate formed is filtered, washed thoroughly with water and dried, to give 0.61 g (83%) of a yellow powder.

Workup

  1. customThe yellow precipitate formed
  2. filtrationis filtered
  3. washwashed thoroughly with water
  4. customdried

Sources & evidence

ORD record
ord-09f9fdb112444c9eb2382dbe19c0de1b
Source dataset
uspto-grants-2015_09
Patent number
US09120819B2

Reaction notes

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