2-Methoxyethylamine → HCID 67506721, compound

HRID 2273602Notes

Reaction equation

HRID 2273602 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].F[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:9][C:8]=1[N+:19]([O-:21])=[O:20]>C(O)C>[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:9][C:8]=1[N+:19]([O-:21])=[O:20]

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 106802714-Fluoro-3-nitro-1,1'-biphenyl

Product 1

HCID 67506721HCID 67506721, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-methoxyethaneamine (1.5 mL) is added to a solution of 4-fluoro-3-nitrobiphenyl (200 mg, 0.92 mmol) in ethanol. The reaction may be stirred at room temperature overnight and concentrated. The residue may be purified by any appropriate method, such as Biotage column chromatography to give N-(2-methoxyethyl)-3-nitrobiphenyl-4-amine (228 mg).

Workup

  1. customThe reaction
  2. concentrationconcentrated
  3. customThe residue may be purified by any appropriate method, such as Biotage column chromatography

Sources & evidence

ORD record
ord-e8320db504304256876ba8993e0abf19
Source dataset
uspto-grants-2015_09
Patent number
US09125901B2

Reaction notes

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