Water → HCID 90016643, compound

HRID 2273808Notes

Reaction equation

HRID 2273808 reaction equation
[NH2:1][C@H:2]([C:6]([OH:8])=[O:7])[CH:3]([CH3:5])[CH3:4].[OH-].[K+:10].O=[C:12]([CH3:19])[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].O>C(OC(C)C)(=O)C>[K+:10].[CH2:17]([O:16][C:14](=[O:15])[CH:13]=[C:12]([NH:1][C@H:2]([C:6]([O-:8])=[O:7])[CH:3]([CH3:5])[CH3:4])[CH3:19])[CH3:18]

Participants

6

Reactant 4

HCID 962WaterHCID 6287L-ValineHCID 8868Ethyl AcetoacetateHCID 14797Potassium Hydroxide

Product 1

HCID 90016643HCID 90016643, compound

Reagents, catalysts & solvents 1

HCID 7915Isopropyl AcetateSolvent

Procedure

L-Valine (117.2 g, 1.0 mol), KOH (85%, 66.0 g, 1 mol) and ethyl 3-oxobutanoate (140.2 mL, 1.1 mol) are dissolved in isopropyl acetate (1 L). The reaction mixture is heated to reflux using a Dean-Stark apparatus. 32 mL water are isolated during 1.75 h. A small quantity of precipitate is formed. 500 mL are distilled off.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureto reflux
  3. customA small quantity of precipitate is formed
  4. distillation500 mL are distilled off

Sources & evidence

ORD record
ord-d3b2d903e1974ea9baeb85ce4d7e4db7
Source dataset
uspto-grants-2015_09
Patent number
US09126896B2

Reaction notes

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