Triethylamine → 2-(2-Oxooxazolidin-3-yl)ethyl methanesulfonate

HRID 227394Notes

Reaction equation

HRID 227394 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:8][CH2:7][O:6][C:5]1=[O:9].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1COCC1>[CH3:17][S:18]([O:1][CH2:2][CH2:3][N:4]1[CH2:8][CH2:7][O:6][C:5]1=[O:9])(=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 768872-Oxazolidinone, 3-(2-hydroxyethyl)-

Product 1

HCID 446271152-(2-Oxooxazolidin-3-yl)ethyl methanesulfonate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The 3-(2-hydroxyethyl)-2-oxazolidinone (Frinton Laboratories, 0.16 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound which was used directly in the next reaction.

Sources & evidence

ORD record
ord-ff776b3c771740be8465187b72af5574
Source dataset
uspto-grants-2009_07
Patent number
US07560481B2

Reaction notes

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