Triethylamine → 2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate

HRID 227397Notes

Reaction equation

HRID 227397 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH2:8][O:7][C:6]([CH3:10])([CH3:9])[O:5]1.C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C1COCC1>[CH3:18][S:19]([O:1][CH2:2][CH2:3][CH:4]1[CH2:8][O:7][C:6]([CH3:10])([CH3:9])[O:5]1)(=[O:21])=[O:20]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 42197542-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol

Product 1

HCID 131945362-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The 4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane (Aldrich, 0.19 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Sources & evidence

ORD record
ord-23faa07c55d849f8927949b623350e81
Source dataset
uspto-grants-2009_07
Patent number
US07560481B2

Reaction notes

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