Piperidine → HCID 53467339, compound

HRID 2274160Notes

Reaction equation

HRID 2274160 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][C:6]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[CH:7][CH:8]=2)[N:3]=1.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>O1CCCC1>[Cl:1][C:2]1[N:11]=[C:10]([N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[C:9]2[C:4](=[CH:5][C:6]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[CH:7][CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 13499313HCID 13499313, compound

Product 1

HCID 53467339HCID 53467339, compoundYield 79.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

1.59 g (5.0 mmol) of 2,4-dichloro-7-morpholin-4-ylquinazoline were suspended in 50 ml of tetrahydrofuran, a solution of 1.24 ml (12.50 mmol) of piperidine in 20 ml of tetrahydrofuran was added at room temperature, and the mixture was stirred for 3 h. Conventional work-up gave 1.33 g of 2-chloro-7-morpholin-4-yl-4-piperidin-1-ylquinazoline (No. 2).

Sources & evidence

ORD record
ord-a6d29ef9d51148a2a0f741d87886efcd
Source dataset
uspto-grants-2015_09
Patent number
US09126952B2

Reaction notes

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