2,2-Diethoxyethylamine → HCID 178467947, compound

HRID 2274463Notes

Reaction equation

HRID 2274463 reaction equation
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].[NH2:10][C:11]1[N:12]([CH2:25][CH3:26])[C:13]2[C:18]([C:19](=[O:23])[C:20]=1[C:21]#[N:22])=[CH:17][CH:16]=[C:15]([I:24])[CH:14]=2>COCCOC.Cl[Cu]>[NH2:10][C:11]1[N:12]([CH2:25][CH3:26])[C:13]2[C:18]([C:19](=[O:23])[C:20]=1[C:21]([NH:6][CH2:5][CH:4]([O:7][CH2:8][CH3:9])[O:3][CH2:1][CH3:2])=[NH:22])=[CH:17][CH:16]=[C:15]([I:24])[CH:14]=2

Participants

5

Reactant 2

HCID 695242,2-DiethoxyethylamineHCID 71001839HCID 71001839, compound

Product 1

HCID 178467947HCID 178467947, compound

Reagents, catalysts & solvents 2

HCID 62652Cuprous chlorideCatalystHCID 80711,2-DimethoxyethaneSolvent

Procedure

0.38 g (2.86 mmol) of aminoacetaldehyde diethylacetal and 0.155 g (1.57 mmol) of CuCl were added to 0.48 .g (1.43 mmol) of 2-amino-1-ethyl-7-iodo-4-oxo-1,4-dihydro-quinoline-3-carbonitrile dissolved in 20 ml of DME. The solution was stirred and irradiated with microwaves for 0.5 hour at 100° C.

Workup

  1. customirradiated with microwaves for 0.5 hour at 100° C.

Sources & evidence

ORD record
ord-f8e96bfddc3d4002819b45695c2008d0
Source dataset
uspto-grants-2015_09
Patent number
US09126972B2

Reaction notes

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