Hydrochloric Acid → HCID 71001800, compound

HRID 2274464Notes

Reaction equation

HRID 2274464 reaction equation
Cl.[NH2:2][C:3]1[N:4]([CH2:26][CH3:27])[C:5]2[C:10]([C:11](=[O:24])[C:12]=1[C:13]([NH:15][CH2:16][CH:17](OCC)OCC)=[NH:14])=[CH:9][CH:8]=[C:7]([I:25])[CH:6]=2.[OH-].[Na+].[NH4+].[OH-]>O>[NH2:2][C:3]1[N:4]([CH2:26][CH3:27])[C:5]2[C:10]([C:11](=[O:24])[C:12]=1[C:13]1[NH:14][CH:17]=[CH:16][N:15]=1)=[CH:9][CH:8]=[C:7]([I:25])[CH:6]=2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14923Ammonium HydroxideHCID 178467947HCID 178467947, compound

Product 1

HCID 71001800HCID 71001800, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.37 ml of a 12N HCl solution were added at 0° C. to a suspension of 0.13 .g (0.28 mmol) of 2-amino-N-(2,2-diethoxy-ethyl)-1-ethyl-7-iodo-4-oxo-1,4-dihydro-quinoline-3-carboxamidine. The reaction mixture was stirred at room temperature during 16 hours. The reaction mixture was than diluted with 0.55 ml of water, basified with 0.32 ml of 1N NaOH solution, and 0.134 ml of an NH4OH solution. The mixture was then filtered and the resulting solid was washed with water, acetonitrile and pentane to give 0.08 g (0.21 mmol) of a brown solid.

Workup

  1. filtrationThe mixture was then filtered
  2. washthe resulting solid was washed with water, acetonitrile and pentane

Sources & evidence

ORD record
ord-2f16a52be11b4e5ea5346667ab4ff3b3
Source dataset
uspto-grants-2015_09
Patent number
US09126972B2

Reaction notes

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