4-Methoxybenzenesulfonyl chloride → HCID 68442814, compound

HRID 227477Notes

Reaction equation

HRID 227477 reaction equation
Cl.[Br:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:14])=[O:13])[C:7]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[C:6]2[S:26]([N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)(=[O:28])=[O:27].C(N(CC)CC)C.[CH3:42][O:43][C:44]1[CH:49]=[CH:48][C:47]([S:50](Cl)(=[O:52])=[O:51])=[CH:46][CH:45]=1>ClCCl>[Br:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:14])=[O:13])[C:7]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[C:6]2[S:26]([N:29]1[CH2:30][CH2:31][N:32]([S:50]([C:47]2[CH:46]=[CH:45][C:44]([O:43][CH3:42])=[CH:49][CH:48]=2)(=[O:52])=[O:51])[CH2:33][CH2:34]1)(=[O:27])=[O:28]

Participants

5

Reactant 3

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 8471TriethylamineHCID 68442079HCID 68442079, compound

Product 1

HCID 68442814HCID 68442814, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution ethyl 5-bromo-1-(phenylsulfonyl)-3-(piperazin-1-ylsulfonyl)-1H-indole-2-carboxylate hydrochloride (20 mg, 0.034 mmol) in 1.0 mL of dichloromethane at room temperature was added triethylamine (0.019 mL, 0.14 mmol), followed by 4-(methoxy)benzenesulfonyl chloride (8.0 mg, 0,041 mmol). After stirring overnight, the solvent was removed under a stream of nitrogen to provide the titled compound.

Workup

  1. customthe solvent was removed under a stream of nitrogen

Sources & evidence

ORD record
ord-9cf55de87a694faeb7007d0c55d14351
Source dataset
uspto-grants-2009_07
Patent number
US07560546B2

Reaction notes

Loading…