Hydrochloric Acid → HCID 57445036, compound

HRID 227480Notes

Reaction equation

HRID 227480 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][C:11]2=[O:23])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[ClH:24]>C(OCC)(=O)C>[ClH:24].[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][NH:13][CH2:12][C:11]2=[O:23])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57445035HCID 57445035, compound

Product 1

HCID 57445036HCID 57445036, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Through a solution of tert-butyl 4-(3-morpholin-4-ylpropyl)-3-oxopiperazine-1-carboxylate (45 mg, 0.14 mmol) in 5 mL of ethyl acetate at 0° C. was bubbled HCl gas for 2 minutes. After stirring an additional 30 minutes, the reaction was concentrated in vacuo to provide the titled product. ESI+MS: 228.4 [M+H]+.

Workup

  1. concentrationthe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-f1b7a322c41142e896dfe8e9871f4ee3
Source dataset
uspto-grants-2009_07
Patent number
US07560546B2

Reaction notes

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