反应详情

温度

60 °C

To a solution of 2-(quinuclidin-3-yl)acetic acid hydrochloride (0.97 g, 4.7 mmol) in DMF (30 mL) was added HATU (1.79 g, 4.72 mmol), 2-(4-bromophenyl)propan-2-amine (1.0 g, 4.7 mmol), and triethylamine (3.9 mL, 28 mmol). The resulting mixture was stirred at 60° C. for 16 h. The mixture was concentrated in vacuo, diluted with EtOAc and washed with brine. The organic layer was dried over Na2SO4 and evaporated to afford crude product, which was purified by silica gel column chromatography (EtOAc/methanol 50/1 to 3/1) to obtain N-(2-(4-bromophenyl)propan-2-yl)-2-(quinuclidin-3-yl)acetamide as a yellow solid (1.3 g, 76%).

1. concentrationThe mixture was concentrated in vacuo
2. additiondiluted with EtOAc
3. washwashed with brine
4. dry with materialThe organic layer was dried over Na2SO4
5. customevaporated
6. customto afford crude product, which
7. customwas purified by silica gel column chromatography (EtOAc/methanol 50/1 to 3/1)