Trifluoroacetic acid → HCID 88861843, compound

HRID 2274985Notes

Reaction equation

HRID 2274985 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C:12]3([CH2:17][CH2:16][N:15]([CH2:18][CH2:19][NH:20]C(=O)OC(C)(C)C)[CH2:14][CH2:13]3)[C:11](=[O:28])[NH:10][CH2:9]2)=[CH:4][CH:3]=1.[C:29]([OH:35])([C:31]([F:34])([F:33])[F:32])=[O:30]>C(Cl)Cl>[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[NH2:20][CH2:19][CH2:18][N:15]1[CH2:14][CH2:13][C:12]2([C:11](=[O:28])[NH:10][CH2:9][C@H:8]2[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68182913HCID 68182913, compound

Product 1

HCID 88861843HCID 88861843, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution containing 130 mg (0.33 mmol) of (S)-tert-butyl 2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethylcarbamate and 5 mL of DCM was added 1 mL of TFA. The reaction mixture was allowed to stir at room temperature overnight. The solvents were removed under reduced pressure and the residue was used without further purification: LCMS m/z: 292.2 (M+H)+.

Workup

  1. customThe solvents were removed under reduced pressure
  2. customthe residue was used without further purification

Sources & evidence

ORD record
ord-f29b0289816a44208ead5c6f4aea5c7a
Source dataset
uspto-grants-2015_09
Patent number
US09127005B2

Reaction notes

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