反应详情

温度

80 °C

To DMF solution (5 mL) of 8-(2-bromo-ethoxy)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile (Compound A7-24, 30 mg, 0.07 mmol), piperazin-2-one (44.9 mg, 0.35 mmol) and N,N-diisopropylethylamine (0.061 mL, 0.35 mmol) were added at room temperature and stirred at 80° C. for 18 hr. After cooling to room temperature, the mixture was extracted with ethyl acetate washed with saturated brine. The organic layer was dried over magnesium sulfate. The drying agent was removed by filtration and the residues obtained after concentration under reduced pressure were purified by preparative TLC (dichloromethane/methanol) to obtain the title compound (white solid, 24 mg, 80%).

1. temperatureAfter cooling to room temperature
2. extractionthe mixture was extracted with ethyl acetate
3. washwashed with saturated brine
4. dry with materialThe organic layer was dried over magnesium sulfate
5. customThe drying agent was removed by filtration
6. customthe residues obtained
7. concentrationafter concentration under reduced pressure
8. customwere purified by preparative TLC (dichloromethane/methanol)