反应详情

温度

-78 °C

2-[1-(2-Bromo-5-methoxy-phenyl)-1-methylethyl]-benzo[b]thiophene (Compound Z3, 40 mg, 0.11 mmol) was dissolved in tetrahydrofuran (0.5 mL), cooled to −78° C., added with n-butyl lithium (1.57 M, hexane solution, 0.07 mL), and the mixture was stirred for 10 min. The reaction mixture was added with dry ice and then maintained for 1 hr. After that, the mixture was added with 0.5 N hydrochloric acid, extracted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate. The residues obtained after concentration under reduced pressure were purified by silica gel column chromatography (ethyl acetate/hexane) to obtain the title compound (22 mg, 55%).

1. temperaturemaintained for 1 hr
2. extractionextracted with ethyl acetate
3. washwashed with water
4. dry with materialThe organic layer was dried over magnesium sulfate
5. customThe residues obtained
6. concentrationafter concentration under reduced pressure
7. customwere purified by silica gel column chromatography (ethyl acetate/hexane)