反应详情

温度

80 °C

To the DMF (28 ml) solution of methanesulfonic acid (2-fluoropyridin-4-yl)methyl ester (1.16 g), sodium cyanide (0.42 g) was added and the mixture was stirred at 80° C. for 1 hr. The mixture was diluted with ethyl acetate (100 ml), and washed with 15% brine and distilled water in order. The organic layer was concentrated and purified by silica gel column (n-hexane/ethyl acetate=5/1) to obtain the title compound (278 mg, 36%).

1. washwashed with 15% brine
2. distillationdistilled water in order
3. concentrationThe organic layer was concentrated
4. custompurified by silica gel column (n-hexane/ethyl acetate=5/1)