反应详情

To the DCM solution (6 ml) of 1-(2-bromo-5-methoxy-phenyl)-cyclopropane carboxylic acid (0.3 g, 1.1 mmol), DMF (2 drops) and oxalyl chloride (0.23 ml, 2.5 mmol) were added at room temperature, and the mixture was stirred at room temperature for 2 hrs. The residues obtained from the reaction solution after concentration under reduced pressure were dissolved in toluene (6 ml), added with (2-hydroxybenzyl)triphenylphosphonium bromide (0.605 g, 1.32 mmol) and TEA (0.46 ml, 3.3 mmol), and the resulting mixture was stirred and heated at 100° C. overnight. The residues obtained after concentration under reduced pressure were purified by silica gel column (hexane:DCM) to obtain the title compound (0.309 g, 81%).

1. customThe residues obtained from the reaction solution
2. concentrationafter concentration under reduced pressure
3. dissolutionwere dissolved in toluene (6 ml)
4. stirringthe resulting mixture was stirred
5. temperatureheated at 100° C. overnight
6. customThe residues obtained
7. concentrationafter concentration under reduced pressure
8. customwere purified by silica gel column (hexane:DCM)