反应详情

Donepezil free base (4.0 gm) is dissolved in a mixture of chloroform (20 ml) and water (1 ml) at 25° C., conc. hydrochloric acid (1.4 ml) is added to the solution and stirred for 3 hours at 25° C. to 30° C. Then diisopropyl ether (100 ml) is added and precipitated solid is filtered off and dried to give 4.0 gm of donepezil hydrochloride monohydrate.

1. customprecipitated solid
2. filtrationis filtered off
3. customdried