Trifluoroacetic acid → HCID 66797653, compound

HRID 2275945Notes

Reaction equation

[C:1]1([C:7]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=[C:9]([N:19]3[C:31]4[CH:30]=[C:29]5[C:32]([CH3:69])([CH3:68])[C:33]6[C:38]([C:28]5=[CH:27][C:26]=4[C:25]4[C:20]3=[CH:21][CH:22]=[CH:23][CH:24]=4)=[CH:37][CH:36]=[CH:35][C:34]=6[C:39]3[CH:40]=[C:41]4[C:49](=[CH:50][CH:51]=3)[N:48](C(OC(C)(C)C)=O)[C:47]3[CH:46]=[C:45]5[C:59]([CH3:67])([CH3:66])[C:60]6[C:65]([C:44]5=[CH:43][C:42]4=3)=[CH:64][CH:63]=[CH:62][CH:61]=6)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O)=O.[OH-].[Na+]>C1(C)C=CC=CC=1.C1(OC)C=CC=CC=1>[C:13]1([C:11]2[N:12]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[N:8]=[C:9]([N:19]3[C:31]4[CH:30]=[C:29]5[C:32]([CH3:69])([CH3:68])[C:33]6[C:38]([C:28]5=[CH:27][C:26]=4[C:25]4[C:20]3=[CH:21][CH:22]=[CH:23][CH:24]=4)=[CH:37][CH:36]=[CH:35][C:34]=6[C:39]3[CH:40]=[C:41]4[C:49](=[CH:50][CH:51]=3)[NH:48][C:47]3[CH:46]=[C:45]5[C:59]([CH3:67])([CH3:66])[C:60]6[C:65]([C:44]5=[CH:43][C:42]4=3)=[CH:64][CH:63]=[CH:62][CH:61]=6)[N:10]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

Conditions

Temperature: 40 °C

Procedure

30.2 g (34.0 mmol) of tert-butyl 7-{10-(4,6-diphenyl-1,3,5-triazin-2-yl)-12,12-dimethyl-10,12-dihydro-10-azaindeno[2,1-b]fluorenyl}-12,12-dimethyl-12H-10-azaindeno[2,1-b]fluorene-10-carboxylate are dissolved in 900 ml of toluene and 200 ml of anisole, and 50 ml of trifluoroacetic acid are subsequently added. The mixture is stirred at 40° C. for 3 h and, when the reaction is complete, neutralised by means of ice-water and 20% NaOH solution. The mixture is extracted with dichloromethane, dried and recrystallised from toluene. The yield is 23.6 g (30 mmol, 88%).

Workup

extractionThe mixture is extracted with dichloromethane
customdried
customrecrystallised from toluene

Sources & evidence

ORD record: ord-0e84f15880834ff99c636ff147d8a4f9
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09126970B2

Reaction notes

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