Sodium Bicarbonate → HCID 66705889, compound

HRID 2276379Notes

Reaction equation

HRID 2276379 reaction equation
O[C@H](C1C=CC=CC=1)C([O:5][CH2:6][C@H:7]([NH2:19])[CH2:8][O:9][C@H:10]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)[CH3:11])=O.C(=O)(O)[O-].[Na+]>CCOC(C)=O>[NH2:19][C@@H:7]([CH2:8][O:9][C@H:10]([C:12]1[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=1)[CH3:11])[CH2:6][OH:5]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 66705909HCID 66705909, compound

Product 1

HCID 66705889HCID 66705889, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A suspension of (R)-2-amino-3-[(S)-1-(4-fluoro-phenyl)-ethoxy]-propan-1-ol (R)-hydroxy-phenyl-acetate in EtOAc was treated with aqueous sodium bicarbonate solution and the mixture was stirred at room temperature until all the solid had dissolved. The phases were separated and the organic layer was dried over MgSO4. The solvent was evaporated to afford (R)-2-amino-3-[(S)-1-(4-fluoro-phenyl)-ethoxy]-propan-1-ol as the free base.

Workup

  1. dissolutionhad dissolved
  2. customThe phases were separated
  3. dry with materialthe organic layer was dried over MgSO4
  4. customThe solvent was evaporated

Sources & evidence

ORD record
ord-9b0dce9882a94cc4a778c21ce5bf4d4d
Source dataset
uspto-grants-2015_09
Patent number
US09132136B2

Reaction notes

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