Sodium Hydroxide → N-{[3-(Trifluoromethyl)phenyl]methylidene}hydroxylamine

HRID 2276395Notes

Reaction equation

HRID 2276395 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=O.[OH-:13].[Na+].[NH2:15]O.Cl>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[N:15][OH:13]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 679903-(Trifluoromethyl)benzaldehydeHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 2777383N-{[3-(Trifluoromethyl)phenyl]methylidene}hydroxylamineYield 93.5%

Procedure

In a similar manner as described in Preparation Example 1, by using 3-(trifluoromethyl)benzaldehyde (34.82 g, 200.0 mmol), sodium hydroxide (12.00 g, 300.0 mmol) and hydrochloric acid hydroxylamine (16.68 g, 240 mmol), a white solid required compound (35.33 g, 187 mmol, 93%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 1

Sources & evidence

ORD record
ord-49dfc682bb7a436ca053255ec074e786
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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