Chlorosuccinimide → HCID 85444714, compound

HRID 2276399Notes

Reaction equation

HRID 2276399 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[CH:6]=[N:7][OH:8].[Cl:14]N1C(=O)CCC1=O>>[OH:8][N:7]=[C:6]([Cl:14])[C:5]1[CH:9]=[CH:10][CH:11]=[C:3]([C:2]([F:12])([F:13])[F:1])[CH:4]=1

Participants

3

Reactant 2

HCID 31398ChlorosuccinimideHCID 2777383N-{[3-(Trifluoromethyl)phenyl]methylidene}hydroxylamine

Product 1

HCID 85444714HCID 85444714, compoundYield 95.3%

Procedure

In a similar manner as described in Preparation Example 9, by using 3-(trifluoromethyl)benzaldehydeoxime (30.0 g, 158.60 mmol), dimethylformimide (300 mL) and N-chlorosuccinimide (23.31 g, 174.46 mmol), a pale yellow solid required compound (33.81 g, 151.22 mmol, 95%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 9

Sources & evidence

ORD record
ord-effc0f617b554d6eb8c35d8b4945467d
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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