Chlorosuccinimide → HCID 86709606, compound

HRID 2276400Notes

Reaction equation

HRID 2276400 reaction equation
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[CH:7]=[N:8][OH:9].[Cl:15]N1C(=O)CCC1=O>CN(C)C=O>[OH:9][N:8]=[C:7]([Cl:15])[C:6]1[CH:10]=[CH:11][CH:12]=[C:4]([O:3][C:2]([F:13])([F:14])[F:1])[CH:5]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 73014310HCID 73014310, compound

Product 1

HCID 86709606HCID 86709606, compoundYield 83.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a similar manner as described in Preparation Example 9, by using dimethylformamide (240 mL), 3-(trifluoromethoxy)benzaldehydeoxime (20.0 g, 97.50 mmol) and N-chlorosuccinimide (14.32 g, 107.26 mmol), a pale yellow solid required compound (19.43 g, 81.10 mmol, 82%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 9

Sources & evidence

ORD record
ord-c8f81c6a47864331921016ae2309ef7a
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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