Hydrochloric Acid → HCID 86612332, compound

HRID 227642Notes

Reaction equation

HRID 227642 reaction equation
[H-].[Na+].[C:3]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=[O:5])[CH3:4].Cl[C:13]1[C:18](Cl)=[CH:17][C:16]([C:20]([F:23])([F:22])[F:21])=[CH:15][N:14]=1.[ClH:24]>C(COC)OC>[Cl:24][C:8]1[CH:7]=[C:6]([C:3](=[O:5])[CH3:4])[CH:11]=[C:10]([C:15]2[C:16]([C:20]([F:22])([F:21])[F:23])=[CH:17][CH:18]=[CH:13][N:14]=2)[CH:9]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7410AcetophenoneHCID 24758Sodium hydrideHCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridine

Product 1

HCID 86612332HCID 86612332, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

To a suspension of 2.6 g (0.065 mol) of sodium hydride 60% in dimethoxyethane at room temperature is added 3.4 mL (0.029 mol) of acetophenone. After 45 min., 5.55 mL (0.038 mol) of 2,3-dichloro-5-(trifluoromethyl)pyridine is added. After 25 min., the reaction mixture is poured over 100 mL of hydrochloric acid 1N, extracted twice with 100 mL of ethyl acetate.

Workup

  1. waitAfter 25 min.
  2. extractionextracted twice with 100 mL of ethyl acetate

Sources & evidence

ORD record
ord-76c9cb88446948d3b7db2dc0433b0306
Source dataset
uspto-grants-2009_07
Patent number
US07560567B2

Reaction notes

Loading…