1-(4-Fluorophenyl)piperazine → HCID 66576939, compound

HRID 2276445Notes

Reaction equation

HRID 2276445 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]([C:13]([OH:15])=O)=[C:11]([CH3:16])[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl.C(N=C=NCCCN(C)C)C.[F:29][C:30]1[CH:35]=[CH:34][C:33]([N:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)=[CH:32][CH:31]=1>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]([C:13]([N:39]3[CH2:38][CH2:37][N:36]([C:33]4[CH:32]=[CH:31][C:30]([F:29])=[CH:35][CH:34]=4)[CH2:41][CH2:40]3)=[O:15])=[C:11]([CH3:16])[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 752601-(4-Fluorophenyl)piperazineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 234478823-(3-Fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylic acid

Product 1

HCID 66576939HCID 66576939, compoundYield 72.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a similar manner as described in Example 1, by using dichloromethane (30 mL), 3-(3-fluorophenyl)-5-methylisoxazol-4-carboxylic acid (407 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(4-fluorophenyl)piperazine (332 mg, 1.84 mmol), a white solid required compound (511 mg, 1.33 mmol, 72%) was obtained.

Sources & evidence

ORD record
ord-468c496294b0409285ef20623898eae1
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

Loading…