[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][(diphenylmethylene)amino]acetonitrile → Amino[3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile hydrochloride

HRID 227650Notes

Reaction equation

HRID 227650 reaction equation
[Cl:1][C:2]1[C:3]([CH:12]([N:15]=C(C2C=CC=CC=2)C2C=CC=CC=2)[C:13]#[N:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1>ClCCl.Cl>[ClH:1].[NH2:15][CH:12]([C:3]1[C:2]([Cl:1])=[CH:7][C:6]([C:8]([F:10])([F:11])[F:9])=[CH:5][N:4]=1)[C:13]#[N:14]

Participants

4

Reactant 1

HCID 22988174[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][(diphenylmethylene)amino]acetonitrile

Product 1

HCID 23078241Amino[3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile hydrochloride

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 6344DichloromethaneSolvent

Procedure

15.0 g of [3-chloro-5-(trifluoromethyl)-2-pyridinyl][(diphenylmethylene)amino]acetonitrile (0.037 mol) are stirred at room temperature for 3 h in a mixture of dichloromethane (15 mL) and hydrochloric acid 10% (15 mL). Phases are separated and the organic phase is washed with 15 mL of hydrochloric acid 10%.

Workup

  1. customPhases are separated
  2. washthe organic phase is washed with 15 mL of hydrochloric acid 10%

Sources & evidence

ORD record
ord-1ec84a41e86c408e96c02642d9290f8c
Source dataset
uspto-grants-2009_07
Patent number
US07560567B2

Reaction notes

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