4-Bromobenzoic acid → 4-Bromobenzoyl chloride

HRID 2276709Notes

Reaction equation

HRID 2276709 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][CH:3]=1.O=S(Cl)[Cl:13]>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:13])=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 114644-Bromobenzoic acidHCID 24386Thionyl Chloride

Product 1

HCID 685154-Bromobenzoyl chlorideYield 97.3%

Conditions

Temperature
80 °C

Procedure

A mixture of 4-bromobenzoic acid (8 g, 39.8 mmoL) in SOCl2 (80 mL) was stirred at 80° C. for 4 hours and then concentrated under reduce pressure. The resulting white solid was used directly for next step without further purification (8.5 g, yield 97.3%).

Workup

  1. concentrationconcentrated
  2. customThe resulting white solid was used directly for next step without further purification (8.5 g, yield 97.3%)

Sources & evidence

ORD record
ord-271086b9d52f4ec0bd8ff95c961c0878
Source dataset
uspto-grants-2015_09
Patent number
US09133105B2

Reaction notes

Loading…