1-Methylpiperazine → HCID 57756881, compound

HRID 227678Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[C:8]([C:11]1[NH:15][CH:14]=[C:13]([C:16]([O:18]CC)=O)[C:12]=1[C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]([NH:30][C:31]2[CH:36]=[C:35]([C:37]([F:40])([F:39])[F:38])[CH:34]=[CH:33][C:32]=2[F:41])=[O:29])=[CH:23][CH:22]=1)(=[O:10])[NH2:9]>>[F:41][C:32]1[CH:33]=[CH:34][C:35]([C:37]([F:38])([F:40])[F:39])=[CH:36][C:31]=1[NH:30][C:28](=[O:29])[NH:27][C:24]1[CH:25]=[CH:26][C:21]([C:12]2[C:13]([C:16]([N:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)=[O:18])=[CH:14][NH:15][C:11]=2[C:8]([NH2:9])=[O:10])=[CH:22][CH:23]=1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 57756911HCID 57756911, compound

Product 1

HCID 57756881HCID 57756881, compound

Procedure

The process is performed in a manner similar to that described in Example 39 but starting with N-methylpiperazine and ethyl 5-carbamoyl-4-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]phenyl}-1H-pyrrole-3-carboxylate. After a similar work-up, 3-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]phenyl}-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carboxamide is obtained; ES+: m/z=533 [M+H]+.

Sources & evidence

ORD record: ord-ab9ddc07f33347689b11948ad3f1f99a
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07560571B2

Reaction notes

Loading…