Hydrochloric Acid → HCID 67296040, compound

HRID 2276846Notes

Reaction equation

HRID 2276846 reaction equation
[ClH:1].[F:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C@H:13]([NH:15]S(C(C)(C)C)=O)[CH3:14])=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[F:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C@H:13]([NH2:15])[CH3:14])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67296116HCID 67296116, compound

Product 1

HCID 67296040HCID 67296040, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 1,4-dioxane solution of 4N hydrochloric acid (5 mL) was added to N-[(1R)-1-(4-fluoronaphthalen-1-yl)ethyl]-2-methylpropane-2-sulfinamide (527 mg, 2.2 mmol), and the mixture was stirred for 30 minutes at room temperature. The precipitate generated was filtered, washed with ether, and was then dried under reduced pressure to give the title compound (358 mg, 70%).

Workup

  1. filtrationThe precipitate generated was filtered
  2. washwashed with ether
  3. customwas then dried under reduced pressure

Sources & evidence

ORD record
ord-ae31bc4e1971455daac926d556d75a8e
Source dataset
uspto-grants-2015_09
Patent number
US09133140B2

Reaction notes

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