3-Aminopiperidine-2,6-dione hydrochloride → Pomalidomide Impurity 10

HRID 2277111Notes

Reaction equation

HRID 2277111 reaction equation
[NH2:1][C:2]1[C:10]([OH:11])=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=O)[C:3]=1[C:12]([OH:14])=O.Cl.[NH2:16][CH:17]1[CH2:22][CH2:21][C:20](=[O:23])[NH:19][C:18]1=[O:24]>>[NH2:1][C:2]1[C:10]([OH:11])=[CH:9][CH:8]=[C:4]2[C:3]=1[C:12](=[O:14])[N:16]([CH:17]1[CH2:22][CH2:21][C:20](=[O:23])[NH:19][C:18]1=[O:24])[C:5]2=[O:7]

Participants

3

Reactant 2

HCID 1345483-Aminopiperidine-2,6-dione hydrochlorideHCID 67861099HCID 67861099, compound

Product 1

HCID 72736581Pomalidomide Impurity 10

Procedure

reacting 3-amino-4-hydroxyphthalic acid with 3-aminopiperidine-2,6-dione hydrochloride, or an enantiomer or a mixture of enantiomers thereof; to form 4-amino-2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione.

Workup

  1. additionan enantiomer or a mixture of enantiomers

Sources & evidence

ORD record
ord-3ed89e9f1e0f44e6abe206855b556c03
Source dataset
uspto-grants-2015_09
Patent number
US09133161B2

Reaction notes

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