Bromomethylcyclopropane → N-((2S)-1-((2-(4-(cyclopropylmethoxy)-2-(difluoromethoxy)phenyl) [1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

HRID 2277328Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]3[CH:22]=[C:21]([O:23][CH2:24][C@@H:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])[N:20]=[CH:19][C:18]=3[N:31]=2)=[C:11]([O:32][CH:33]([F:35])[F:34])[CH:10]=1)[C:2]1C=CC=[CH:4][CH:3]=1.BrCC1CC1>>[CH:2]1([CH2:1][O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[O:16][C:17]4[CH:22]=[C:21]([O:23][CH2:24][C@@H:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])[N:20]=[CH:19][C:18]=4[N:31]=3)=[C:11]([O:32][CH:33]([F:35])[F:34])[CH:10]=2)[CH2:3][CH2:4]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 86731419HCID 86731419, compound

Product 1

HCID 86731418N-((2S)-1-((2-(4-(cyclopropylmethoxy)-2-(difluoromethoxy)phenyl) [1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

Procedure

Using N-((2S)-1-((2-(4-(benzyloxy)-2-(difluoromethoxy)phenyl) [1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and (bromomethyl)cyclopropane, and in the same manner as in Step D of Example 68, the title compound was obtained.

Sources & evidence

ORD record: ord-42aecfc56770407cb77ccc207df6cf3d
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09133129B2

Reaction notes

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