HRID227734

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

结构：Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.F[P-](F)(F)(F)(F)F

HCID2733179

PyBroP

C12H24BrF6N3P2

结构：CC1=C(C(=O)O)C(c2ccc(C(F)(F)F)cc2)NC(=O)N1

HCID53482105

6-Methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

C13H11F3N2O3

HCID69067693

未命名化合物

PRODUCTS

生成物

结构：CC1=C(C(=O)Nc2ccc3[nH]nc(Nc4cc(F)cc(F)c4)c3c2)C(c2ccc(C(F)(F)F)cc2)NC(=O)N1

HCID57755825

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The titled compound was prepared following the procedure of Example 175 using 6-Methyl-2-oxo-4-(4-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid, N3-(3,5-difluoro-phenyl)-1H-indazole-3,5-diamine, PyBroP and diisopropylethylamine in methylene chloride. MS (ESI) m/z=543 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ca989b87fa7942c1b3ce86c2e8db93d2
来源数据集: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07560467B2
来源说明: uspto-grants-2009_07

反应 SMILES

[CH3:1][C:2]1[NH:7][C:6](=[O:8])[NH:5][CH:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[C:3]=1[C:19]([OH:21])=O.[F:22][C:23]1[CH:24]=[C:25]([NH:30][C:31]2[C:39]3[C:34](=[CH:35][CH:36]=[C:37]([NH2:40])[CH:38]=3)[NH:33][N:32]=2)[CH:26]=[C:27]([F:29])[CH:28]=1.C1CN([P+](Br)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.C(N(C(C)C)CC)(C)C>C(Cl)Cl>[F:22][C:23]1[CH:24]=[C:25]([NH:30][C:31]2[C:39]3[C:34](=[CH:35][CH:36]=[C:37]([NH:40][C:19]([C:3]4[CH:4]([C:9]5[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:18])[F:16])=[CH:11][CH:10]=5)[NH:5][C:6](=[O:8])[NH:7][C:2]=4[CH3:1])=[O:21])[CH:38]=3)[NH:33][N:32]=2)[CH:26]=[C:27]([F:29])[CH:28]=1