HRID2277378
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
To a solution of N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (300 mg, 0.54 mmol) in DCM/MeOH (30 mL, v/v=1:2) was added 1 N HCl in EtOAc (5.4 mL). The mixture was stirred at room temperature for 30 minutes. The solid was collected by filtration, washed with ethanol (20 mL) to give the title compound as a white solid (304 mg, 95.2%)
WORKUP
后处理
- filtrationThe solid was collected by filtration
- washwashed with ethanol (20 mL)