反应详情

温度

30 °C

To a suspension of 4-(4-nitrophenoxy)quinolin-7-ol (10 g, 35.5 mmol) in THF (35 mL)/aq. NaOH (37.8 g, 7.4%) was added (R)-2-methyloxirane (10.3 g, 177.3 mmol). The reaction was stirred at 30° C. for 18 hours then concentrated in vacuo. The mixture was diluted with EtOAc (50 mL). The organic phase was separated and concentrated in vacuo. The residue was purified by a column chromatography on silica gel (EtOAc/PE=1:1) to furnish the title compound as a yellow solid (3.6 g, 29.9%).

1. concentrationthen concentrated in vacuo
2. additionThe mixture was diluted with EtOAc (50 mL)
3. customThe organic phase was separated
4. concentrationconcentrated in vacuo
5. customThe residue was purified by a column chromatography on silica gel (EtOAc/PE=1:1)