Hydrochloric Acid → HCID 86685963, compound

HRID 2277672Notes

Reaction equation

HRID 2277672 reaction equation
C([Si](C)(C)[O:6][C@@H:7]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[C:14]([N:18]3[CH2:27][CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[C:23]([Cl:28])[CH:24]=4)[C:19]3=[O:29])[CH:15]=[N:16][CH:17]=2)[CH2:8]1)(C)(C)C.Cl>O1CCOCC1>[Cl:28][C:23]1[CH:24]=[C:25]2[C:20](=[CH:21][CH:22]=1)[C:19](=[O:29])[N:18]([C:14]1[CH:15]=[N:16][CH:17]=[C:12]([N:9]3[CH2:10][CH2:11][C@@H:7]([OH:6])[CH2:8]3)[CH:13]=1)[CH2:27][CH2:26]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86685964HCID 86685964, compound

Product 1

HCID 86685963HCID 86685963, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to the procedure described in example 135 [D], 2-{5-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-1-yl]-pyridin-3-yl}-6-chloro-3,4-dihydro-2H-isoquinolin-1-one was deprotected with 4M HCl in dioxane to give the title compound as a white foam. MS: 344.0 (M+H+).

Sources & evidence

ORD record
ord-a3af7dc5c4334e0ba27c4a09c7320142
Source dataset
uspto-grants-2015_09
Patent number
US09133158B2

Reaction notes

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