Potassium Carbonate → HCID 89239694, compound

HRID 2277740Notes

Reaction equation

HRID 2277740 reaction equation
C(=O)([O-])[O-].[K+].[K+].FC(F)(F)C([N:11]=[S:12]([CH3:24])([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=1)=[O:13])=O>CO.C(OCC)(=O)C.[Cl-].[Na+]>[CH3:24][S:12]([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=1)(=[NH:11])=[O:13]

Participants

6

Reactant 2

HCID 11430Potassium CarbonateHCID 89451651HCID 89451651, compound

Product 1

HCID 89239694HCID 89239694, compoundYield 79%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 5234Sodium ChlorideSolventHCID 8857Ethyl AcetateSolvent

Procedure

Potassium carbonate (56.9 g; 411.8 mmol) was added to a solution of (rac)-2,2,2-trifluoro-N-[methyl(3-nitrobenzyl)oxido-λ6-sulfanylidene]acetamide (25.6 g; 82.4 mmol) in MeOH (1768 mL) at room temperature. The batch was stirred for 1 hour at room temperature before it was diluted with ethyl acetate and saturated aqueous sodium chloride solution. After extraction with ethyl acetate (2×) the combined organic phases were dried (sodium sulfate), filtered and concentrated to give the desired product (13.9 g; 65.1 mmol).

Workup

  1. extractionAfter extraction with ethyl acetate (2×) the combined organic phases
  2. dry with materialwere dried (sodium sulfate)
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-803d7ddd44944bf486ff79ec386e05dd
Source dataset
uspto-grants-2015_09
Patent number
US09133171B2

Reaction notes

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