Diisopropylethylamine → HCID 22061094, compound

HRID 2277794Notes

Reaction equation

HRID 2277794 reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.Cl.[CH3:11][N:12]1[CH:16]=[C:15]([NH2:17])[CH:14]=[C:13]1[C:18]([O:20][CH3:21])=[O:19].C(N(C(C)C)CC)(C)C>>[Br:1][C:2]1[C:3]([NH:17][C:15]2[CH:14]=[C:13]([C:18]([O:20][CH3:21])=[O:19])[N:12]([CH3:11])[CH:16]=2)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 2899735-Bromo-2,4-dichloropyrimidineHCID 2794656methyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate hydrochloride

Product 1

HCID 22061094HCID 22061094, compound

Procedure

In like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro 4-pyrimidineamine, 5-bromo-2,4-dichloropyrimidine and N-methyl-2-carbomethoxy-4-aminopyrrole hydrochloride with added diisopropylethylamine were reacted to produce the desired product 5-bromo-2-chloro-N—(N-methyl-2-carbomethoxypyrrol-4-yl)-4-pyrimidineamine. 1H NMR (CDCl3): δ 8.21 (s, 1H), 7.43 (d, 1H, J=1.8 Hz), 7.13 (br s, 1H), 6.84 (d, 1H, J=1.8 Hz), 3.95 (s, 3H), 3.82 (s, 3H); LCMS: ret. time: 26.96 min.; purity: 91%; MS (m/e): 346 (MH+).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-342ca07e3ac84539aed64061d5ea7f2d
Source dataset
uspto-grants-2015_09
Patent number
US09133133B2

Reaction notes

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