Pyrrolidine → HCID 89677025, compound

HRID 2278239Notes

Reaction equation

HRID 2278239 reaction equation
[Cl:1][C:2]1[C:3](F)=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>>[Cl:1][C:2]1[C:3]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 7363353-Chloro-2-fluorobenzaldehyde

Product 1

HCID 89677025HCID 89677025, compound

Procedure

The title compound was synthesized from 3-chloro-2-fluorobenzaldehyde and pyrrolidine as described in Example 67, Step 1 (800 mg, 30%). 1H NMR 300 MHz (CDCl3) δ 10.36 (s, 1H), 7.71-7.73 (m, 1H), 7.59-7.61 (m, 1H), 7.18-7.26 (m, 1H), 3.33-3.42 (m, 4H), 2.01-2.10 (m, 4H). LCMS (ESI, m/z): 210 [M+H]+.

Sources & evidence

ORD record
ord-bad290b96ebf42cabc90acfd00607935
Source dataset
uspto-grants-2015_09
Patent number
US09133148B2

Reaction notes

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