Hydrochloric Acid → HCID 89525783, compound

HRID 2278353Notes

Reaction equation

HRID 2278353 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]([NH:17]S(C(C)(C)C)=O)[CH2:8][O:9][Si](C(C)(C)C)(C)C)[S:5][CH:6]=1.[ClH:24]>CO.O1CCOCC1>[Cl-:24].[Br:1][C:2]1[CH:3]=[C:4]([CH:7]([NH3+:17])[CH2:8][OH:9])[S:5][CH:6]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 89525673HCID 89525673, compound

Product 1

HCID 89525783HCID 89525783, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
0 °C

Procedure

N-[1-(4-bromothiophen-2-yl)-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl]-2-methylpropane-2-sulfinamide (660 mg, 1.5 mmol) was dissolved in MeOH (15 mL) and the solution was cooled to 0° C., after which HCl (1.87 mL of a 4M solution in dioxane, 7.49 mmol) was added and the mixture was stirred for 120 minutes. The solvents were removed by coevaporation with toluene.

Workup

  1. customThe solvents were removed by coevaporation with toluene

Sources & evidence

ORD record
ord-6092054cc1da464ab4b3fa2ad91a87bd
Source dataset
uspto-grants-2015_09
Patent number
US09133157B2

Reaction notes

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