Hydrochloric Acid → HCID 89525796, compound

HRID 2278360Notes

Reaction equation

HRID 2278360 reaction equation
[Si:1]([O:8][CH2:9][CH:10]([N:24]([CH2:34][CH2:35][CH:36]([CH3:38])[CH3:37])[S:25]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)(=[O:27])=[O:26])[C:11]1[S:12][CH:13]=[C:14]([CH2:16][NH:17]S(C(C)(C)C)=O)[CH:15]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Cl>CO.O1CCOCC1>[NH2:17][CH2:16][C:14]1[CH:15]=[C:11]([CH:10]([N:24]([CH2:34][CH2:35][CH:36]([CH3:38])[CH3:37])[S:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)(=[O:27])=[O:26])[CH2:9][O:8][Si:1]([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:2])[CH3:3])[S:12][CH:13]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 89525739HCID 89525739, compound

Product 1

HCID 89525796HCID 89525796, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-{[(tert-butylsulfinyl)amino]-methyl}thiophen-2-yl)ethyl]-N-(3-methylbutyl)benzenesulfonamide (127 mg, 0.211 mmol) was dissolved in 2.1 mL MeOH. The mixture was cooled to 0° C. before the addition of HCl (0.264 mL of a 4 M solution in dioxane, 1.06 mmol). The mixture was stirred for 120 minutes and the solvents were removed by co-evaporation with toluene.

Workup

  1. customthe solvents were removed by co-evaporation with toluene

Sources & evidence

ORD record
ord-3c4155fedeb940e788172418cf6dd126
Source dataset
uspto-grants-2015_09
Patent number
US09133157B2

Reaction notes

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