反应详情

Into a 100-ml, 4-necked flask equipped with a stirrer were introduced 1.5 g of O-methyl-N-nitroisourea, 11 g of water, 3 g of sodium chloride and 2 g of methylamine hydrochloride, and the resulting material was maintained at 20 degree centigrade. Thereafter, 0.1 g of sodium hydrogen carbonate was added to the mixture and the mixture was stirred at 20 degree centigrade for 16 hours. Then, while stirring the reaction mixture, 0.1 g of concentrated hydrochloric acid and 200 ml of water were added to the mixture to give a homogenious aqueous solution of N,O-dimethyl-N′-nitroisourea, which was analyzed by HPLC. In the aqueous solution, 1.2 g of N,O-dimethyl-N′-nitroisourea was contained, and the reaction yield was 73%.

1. customInto a 100-ml, 4-necked flask equipped with a stirrer
2. temperaturethe resulting material was maintained at 20 degree centigrade
3. additionwere added to the mixture