Pyrrolidine → HCID 131733469, compound

HRID 2278401Notes

Reaction equation

HRID 2278401 reaction equation
[Br:1][C:2]1[C:7]([CH2:8][CH3:9])=[C:6]([N+:10]([O-:12])=[O:11])[CH:5]=[CH:4][C:3]=1[CH3:13].[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1.[CH3:19]N(C=O)C.CC(N(C)C)=O>>[Br:1][C:2]1[C:3]([CH2:13][CH3:19])=[CH:4][CH:5]=[C:6]([N+:10]([O-:12])=[O:11])[C:7]=1[CH:8]=[CH:9][N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 22628260N,N-dimethylformamide N,N-dimethylacetamideHCID 89739001HCID 89739001, compound

Product 1

HCID 131733469HCID 131733469, compound

Procedure

The product of Step 2 (13 g, 53 mmol) and pyrrolidine (2.3 mL) in DMF/DMA (150 ml) were heated at reflux overnight. The mixture was cooled and then concentrated to give the crude title compound, which was used directly in the next step.

Workup

  1. temperatureat reflux overnight
  2. temperatureThe mixture was cooled
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-2db6cc5975e64e0c8c6765a7e888c0d6
Source dataset
uspto-grants-2015_09
Patent number
US09133180B2

Reaction notes

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