Dimethylformamide dimethyl acetal → HCID 67513546, compound

HRID 2278413Notes

Reaction equation

HRID 2278413 reaction equation
[CH3:1][C:2]1[O:3][CH:4]=[CH:5][C:6]=1[C:7](=[O:16])[CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([CH3:15])[CH:10]=1.CO[CH:19](OC)[N:20]([CH3:22])[CH3:21]>>[CH3:19][N:20]([CH3:22])[CH:21]=[C:8]([C:9]1[CH:14]=[CH:13][N:12]=[C:11]([CH3:15])[CH:10]=1)[C:7]([C:6]1[CH:5]=[CH:4][O:3][C:2]=1[CH3:1])=[O:16]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 67513136HCID 67513136, compound

Product 1

HCID 67513546HCID 67513546, compoundYield 99.9%

Conditions

Temperature
100 °C

Procedure

A mixture of 1-(2-methyl-3-furanyl)-2-(2-methyl-4-pyridinyl)ethanone (0.430 g, 2.000 mmol) in N,N-dimethylformamide dimethyl acetal (0.266 ml, 2 mmol) was heated at 100° C. for 2 hours. The mixture was cooled to room temperature and the solvent was evaporated to give the title compound (540 mg) which was used crude in the next step. LC/MS [M+H]+=271.

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-069cedb04e6f4fd4af7b684683dcad07
Source dataset
uspto-grants-2015_09
Patent number
US09133178B2

Reaction notes

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