3-Chloro-4-fluoroaniline → HCID 57406394, compound

HRID 2278528Notes

Reaction equation

[Na].[F:2][CH2:3][CH:4]1[O:9][CH2:8][CH2:7][N:6]([C:10]2[N:11]=[C:12]([CH2:18][C:19]([OH:21])=O)[N:13]([CH3:17])[C:14](=[O:16])[CH:15]=2)[CH2:5]1.[Cl:22][C:23]1[CH:24]=[C:25]([CH:27]=[CH:28][C:29]=1[F:30])[NH2:26]>>[F:2][CH2:3][CH:4]1[O:9][CH2:8][CH2:7][N:6]([C:10]2[N:11]=[C:12]([CH2:18][C:19]([NH:26][C:25]3[CH:27]=[CH:28][C:29]([F:30])=[C:23]([Cl:22])[CH:24]=3)=[O:21])[N:13]([CH3:17])[C:14](=[O:16])[CH:15]=2)[CH2:5]1

Participants

Reactant 3

HCID 97083-Chloro-4-fluoroaniline

HCID 5360545Sodium

HCID 86699264HCID 86699264, compound

Product 1

HCID 57406394HCID 57406394, compound

Procedure

The product is prepared by following the procedure described in step 3b of example 1b, but using 250 mg of the sodium salt of [4-(2-fluoromethylmorpholin-4-yl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]acetic acid and 237 mg of 3-chloro-4-fluoroaniline. 97 mg of 2-[4-(2-fluoromethylmorpholin-4-yl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(3-chloro-4-fluorophenyl)acetamide are obtained in the form of a white solid, the characteristics of which are the following:

Workup

customThe product is prepared

Sources & evidence

ORD record: ord-691d0c8af0e84d08885f327f9d6cb16d
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09133168B2

Reaction notes

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