反应详情

温度

110 °C

3.5 ml of DMF-DMA (N,N-dimethylformamide-dimethyl acetal) are added to a solution of 1 g of 2-methyl-3-nitrobenzotrifluoride in 6 ml of N,N-dimethylformamide. The reaction medium is heated at 110° C. until the starting material has disappeared, then poured into water and extracted with ethyl acetate. The organic phases are washed successively with a 10% sodium bicarbonate solution, a 10% ammonium chloride solution and a saturated sodium chloride solution, dried over magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure so as to give 1.2 g of dimethyl[(E)-2-(2-nitro-6-trifluoromethylphenyl)vinyl]amine in the form of an oil which is used in the next step.

1. extractionextracted with ethyl acetate
2. washThe organic phases are washed successively with a 10% sodium bicarbonate solution
3. dry with materiala 10% ammonium chloride solution and a saturated sodium chloride solution, dried over magnesium sulfate
4. filtrationfiltered
5. concentrationThe filtrate is concentrated under reduced pressure so as