Lithium Hydroxide → HCID 58449398, compound

HRID 2278721Notes

Reaction equation

HRID 2278721 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[C:16]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][C:19]3=[O:24])[CH:17]=2)[C:11]([O:13]C)=[O:12])=[N:6][CH:7]=1.[OH-].[Li+]>CO>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[C:16]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][C:19]3=[O:24])[CH:17]=2)[C:11]([OH:13])=[O:12])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 58449365HCID 58449365, compound

Product 1

HCID 58449398HCID 58449398, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A round bottom flask was charged with methyl 3-(5-methylpyridin-2-yl)-5-(3-oxomorpholino)benzoate (50 mg, 0.15 mmol), methanol (1.2 mL) and lithium hydroxide (11 mg, 0.46 mmol) and the reaction mixture was stirred at room temperature for 1 h. The reaction mixture was acidified to pH=5 and concentrated under reduced pressure to get the title compound-LiCI mixture as a white solid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-21141de6d3f1442b89a2ad517e57d420
Source dataset
uspto-grants-2015_09
Patent number
US09133122B2

Reaction notes

Loading…