Methylamine → HCID 70557165, compound

HRID 2278794Notes

Reaction equation

HRID 2278794 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][O:9][C:10]1[C:15]([CH3:16])=[CH:14][C:13]([C:17]2[N:21]=[C:20]([C:22]3[CH:27]=[C:26]([O:28][CH3:29])[N:25]=[C:24]([CH:30]4[CH2:34][CH2:33][CH2:32][CH2:31]4)[CH:23]=3)[O:19][N:18]=2)=[CH:12][C:11]=1[CH2:35][CH3:36])(=O)=O.[CH3:37][NH2:38]>C1COCC1>[CH:30]1([C:24]2[CH:23]=[C:22]([C:20]3[O:19][N:18]=[C:17]([C:13]4[CH:14]=[C:15]([CH3:16])[C:10]([O:9][CH2:8][CH2:7][CH2:6][NH:38][CH3:37])=[C:11]([CH2:35][CH3:36])[CH:12]=4)[N:21]=3)[CH:27]=[C:26]([O:28][CH3:29])[N:25]=2)[CH2:34][CH2:33][CH2:32][CH2:31]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 86702021HCID 86702021, compound

Product 1

HCID 70557165HCID 70557165, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-(4-(5-(2-Cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)-N-methylpropan-1-amine (941 mg) is prepared in analogy to Example 29 starting from 3-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propyl methanesulfonate (700 mg, 1.36 mmol) and 2 M methyl amine solution in THF (20 mL); LC-MS: tR=0.96 min, [M+H]+=451.29.

Sources & evidence

ORD record
ord-1354d9d0778a42df96c92739599acf5e
Source dataset
uspto-grants-2015_09
Patent number
US09133179B2

Reaction notes

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